Increase in NF- B Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9 1237T/C Polymorphism Is Associated with Helicobacter pylori-Induced Gastric Disease
نویسندگان
چکیده
Increase in NFB Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9 1237T/C Polymorphism Is Associated with Helicobacter pylori-Induced Gastric Disease Mike Tsz Hin Ng, Rob van’t Hof, Julie C. Crockett, Mairi E. Hope, Susan Berry, John Thomson, Mairi H. McLean, Kenneth E. L. McColl, Emad M. El-Omar, and Georgina L. Hold* Division of Applied Medicine, Aberdeen University, Aberdeen, United Kingdom; Rheumatic Diseases Unit, Molecular Medicine Centre, Edinburgh University, Edinburgh, United Kingdom; and Department of Medicine and Therapeutics, Glasgow University, Western Infirmary, Glasgow, United Kingdom
منابع مشابه
Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease.
Colonization of the gastric mucosa by Helicobacter pylori can lead to serious clinical outcomes, including gastric cancer. Toll-like receptors (TLRs) play an important role in the host response to H. pylori through the recognition of pathogen-associated molecular patterns. TLR9, in particular, is partly responsible for initiating bacterial induced immunity by binding unmethylated CpG-DNA, which...
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